Plasmodium yoelii, like most parasitic members of the Plasmodium family, utilizes two types of ribosome. While both are always present to some extent, S-type is far more numerous during the parasite's sporozoite (mosquito) stages, while the A-type is expressed more during asexual (mammalian) stages. The purpose of this project is to see whether an RNA-based tag, Mango-2, could be added to S-type ribosomes to act as a handle for purification in sporozoite stages without damaging the function and folding of the ribosome.